If elected, he would be the third vice-president from Andhra Pradesh. The list includes Sarvepalli Radhakrishnan and VV Giri, both of whom later became President.
He was elected to the Rajya Sabha thrice from Karnataka and once from Rajasthan.
The veteran leader served as the BJP national president from July 2002 to October 2004. He quit the post after the party's defeat in the 2004 Lok Sabha elections.
Mr Naidu served as the Rural Development Minister in the NDA government headed by Atal Bihari Vajpayee.
In PM Narendra Modi's government, he held the portfolios of Parliamentary Affairs, Information and Broadcasting and Urban Development.
As the Urban Development minister, he started several urban missions, including the Smart City Mission, Atal Mission, Swachh Bharat Mission and Housing for All. He was also instrumental in launching the 'Pradhan Mantri Gram Sadak Yojana' as the rural development minister.
Though Mr Naidu is from the South, he learnt Hindi and addressed many rallies in north India. He is an enthusiastic proponent of Hindi as the national language.
Coming from an agricultural family of Andhra Pradesh's Nellore district, Mr Naidu started his political career in 1973 as a student leader and later joined the Jan Sangh.
He was elected twice to the Andhra Pradesh Legislative Assembly.